Exercise-intensity dependent alterations in plasma redox status do not reflect skeletal muscle redox-sensitive protein signaling
نویسندگان
چکیده
منابع مشابه
Redox signaling in skeletal muscle: role of aging and exercise.
Skeletal muscle contraction is associated with the production of ROS due to altered O2 distribution and flux in the cell. Despite a highly efficient antioxidant defense, a small surplus of ROS, such as hydrogen peroxide and nitric oxide, may serve as signaling molecules to stimulate cellular adaptation to reach new homeostasis largely due to the activation of redox-sensitive signaling pathways....
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Physical inactivity, excess energy consumption, and obesity are associated with elevated systemic oxidative stress and the sustained activation of redox-sensitive stress-activated protein kinase (SAPK) and mitogen-activated protein kinase signaling pathways. Sustained SAPK activation leads to aberrant insulin signaling, impaired glycemic control, and the development and progression of cardiomet...
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Changes in population demographics have seen an increase in human lifespan coupled with an increase in many age associated disorders that determine quality of life including, sarcopenia, and frailty. Closing the gap between life expectancy and healthy aging has now become a research priority in many countries. Skeletal muscle comprises up to 40% of body mass and the inhibition or delay of the p...
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1Department of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616, USA 2Cardiac Aging & Redox Signaling Laboratory, Division of Molecular & Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA 3Division of Cardiovascular Medicine, Department of Medicine, University of Utah School of Medicine, Salt Lake City, U...
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Intensive and exhaustive exercise induces an activation of blood T-lymphocytes, which seems to be terminated by apoptotic processes in the postexercise period. Here, we report that exercise-induced T-lymphocyte apoptosis is a systemic phenomenon occurring in various lymphoid and nonlymphoid tissues. The apoptosis rate could be related to exercise intensity and type. Although in some tissues, su...
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ژورنال
عنوان ژورنال: Journal of Science and Medicine in Sport
سال: 2018
ISSN: 1440-2440
DOI: 10.1016/j.jsams.2017.06.017